{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344274/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344274"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Blood transcriptional variation is associated with clinical and neuroimaging phenotypes in essential tremor","description":"We examined whether peripheral blood gene expression differs in essential tremor (ET) and relates to clinical or neuroanatomical variation. Blood RNA-seq was analysed in 38 individuals with ET and 37 controls. Differential expression, phenotype associations, co-expression networks, and cross-tissue concordance with ET cerebellar RNA-seq were assessed. Four genes were significantly upregulated in ET: CXCL5, HSPB1, CLEC7A, and PRDX6. Diagnostic effects were otherwise limited, but within ET, gene expression showed stronger associations with cognition and regional brain structure, including immune, mitochondrial, and erythroid/vascular transcriptional modules. Blood RNA-seq shows modest diagnostic differences in ET but more substantial transcriptional associations with phenotypic heterogeneity.","dates":{"publication":"2026/09/16"},"accession":"GSE344274","cross_references":{"GSM":["GSM9973989","GSM9973988","GSM9973987","GSM9973986","GSM9973985","GSM9973984","GSM9973983","GSM9973982","GSM9973981","GSM9973980","GSM9973979","GSM9973978","GSM9973977","GSM9973976","GSM9973975","GSM9973974","GSM9973973","GSM9973972","GSM9973971","GSM9973970","GSM9974023","GSM9974022","GSM9974021","GSM9974020","GSM9973969","GSM9973968","GSM9973967","GSM9973966","GSM9973965","GSM9973964","GSM9974019","GSM9973963","GSM9974018","GSM9974017","GSM9973962","GSM9973961","GSM9974016","GSM9973960","GSM9974015","GSM9974014","GSM9974013","GSM9974012","GSM9974011","GSM9974010","GSM9973999","GSM9974009","GSM9973998","GSM9973997","GSM9974008","GSM9974007","GSM9973996","GSM9974006","GSM9973995","GSM9973994","GSM9974005","GSM9974004","GSM9973993","GSM9973992","GSM9974003","GSM9974002","GSM9973991","GSM9974001","GSM9973990","GSM9974000"],"GPL":["34284"],"GSE":["344274"],"taxon":["Homo sapiens"]}}