GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344274/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344274GEOGSEfalseBlood transcriptional variation is associated with clinical and neuroimaging phenotypes in essential tremorWe examined whether peripheral blood gene expression differs in essential tremor (ET) and relates to clinical or neuroanatomical variation. Blood RNA-seq was analysed in 38 individuals with ET and 37 controls. Differential expression, phenotype associations, co-expression networks, and cross-tissue concordance with ET cerebellar RNA-seq were assessed. Four genes were significantly upregulated in ET: CXCL5, HSPB1, CLEC7A, and PRDX6. Diagnostic effects were otherwise limited, but within ET, gene expression showed stronger associations with cognition and regional brain structure, including immune, mitochondrial, and erythroid/vascular transcriptional modules. Blood RNA-seq shows modest diagnostic differences in ET but more substantial transcriptional associations with phenotypic heterogeneity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 sapiens