{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344388/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Rattus norvegicus"],"gds_type":["Expression profiling by array"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344388"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Identification of osteopontin as a positional and functional candidate gene for cardiac hypertrophy in the SHRSP rat","description":"Left ventricular mass is a highly heritable, polygenic trait and linkage studies in WKY and SHRSP rats identified a quantitative trait locus for left ventricular mass index on chromosome 14. Congenic strains, where trait-associated genetic loci are introduced into “healthy backgrounds, identify causal mediators relevant to human disease. Chromosome 14 congenic (WKY.SPGla14a), WKY, and SHRSP strains underwent cardiac phenotyping and transcriptome profiling at; 1-3 days (neonate), 5 weeks, and 16-weeks). Gene expression was assessed in the whole heart of 1-day neonate rats, and the LV of 5 and 16 week rats (N=3/strain) using the RatRef-12 v1.0 microarray chip (Illumina). Whole hearts from 1-day neonate animals were collected, weighted and snap frozen for RNA extraction. LV was snap frozen following dissection and weighting from 5 and 16 week rats. RNA was extracted from frozen heart/LV tissue using RNeasy kits according to the manufacturer’s protocol (Qiagen). Biotinylated amplified target cDNA was prepared and hybridised to the chip.","dates":{"publication":"2026/08/27"},"accession":"GSE344388","cross_references":{"GSM":["GSM9978234","GSM9978233","GSM9978214","GSM9978236","GSM9978235","GSM9978238","GSM9978216","GSM9978237","GSM9978215","GSM9978218","GSM9978217","GSM9978239","GSM9978219","GSM9978230","GSM9978232","GSM9978231","GSM9978245","GSM9978223","GSM9978244","GSM9978222","GSM9978225","GSM9978247","GSM9978224","GSM9978246","GSM9978227","GSM9978249","GSM9978248","GSM9978226","GSM9978229","GSM9978228","GSM9978241","GSM9978240","GSM9978243","GSM9978221","GSM9978242","GSM9978220"],"GPL":["6101"],"GSE":["344388"],"taxon":["Rattus norvegicus"]}}