{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344432/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344432"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Rewiring of integrin signaling and cell-cycle deregulation drive SMARCB1-deficient epithelioid sarcoma","description":"Epithelioid sarcoma (EPS) is an aggressive soft-tissue sarcoma characterized by loss of the chromatin-remodeling subunit SMARCB1. The oncogenic programs driving EPS remain poorly understood. Through CRISPR loss-of-function screens, we identified conserved dependencies on integrin signaling components and cyclin-dependent kinases (CDKs). Genetic disruption of integrin subunit alpha V (ITGAV)-centered signaling impaired epithelial cluster formation and reduced MYC expression. SMARCB1 re-expression phenocopied these effects and revealed that SMARCB1 loss selectively represses context-dependent integrin subunits while preserving an ITGAV-centered pro-survival axis associated with altered BAF complex occupancy. Analysis of EPS cell lines and primary tumors revealed frequent genetic or epigenetic inactivation of CDKN2A/p16, indicating that loss of cell-cycle control is a key cooperating event in EPS development and providing a mechanistic rationale for targeting CDK4/6. Together, these findings establish integrin-driven oncogenic signaling coupled with disruption of cell-cycle control as a central oncogenic program in EPS and identify actionable therapeutic vulnerabilities.","dates":{"publication":"2026/08/21"},"accession":"GSE344432","cross_references":{"GSM":["GSM9978931","GSM9978930","GSM9978911","GSM9978933","GSM9978932","GSM9978910","GSM9978935","GSM9978913","GSM9978934","GSM9978912","GSM9978937","GSM9978915","GSM9978914","GSM9978936","GSM9978917","GSM9978939","GSM9978938","GSM9978916","GSM9978919","GSM9978918","GSM9978909","GSM9978940","GSM9978920","GSM9978942","GSM9978941","GSM9978922","GSM9978921","GSM9978924","GSM9978923","GSM9978926","GSM9978904","GSM9978925","GSM9978903","GSM9978928","GSM9978906","GSM9978905","GSM9978927","GSM9978908","GSM9978929","GSM9978907"],"GPL":["24676"],"GSE":["344432"],"taxon":["Homo sapiens"]}}