GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344436/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344436GEOGSEfalseA tunable immune-evasion function of Zika virus NS5 governs viral fitness and pathogenesisZika virus (ZIKV) nonstructural protein 5 (NS5) antagonizes host antiviral immunity, but how this immune-evasion activity is regulated to support viral fitness and pathogenesis remains incompletely understood. In this study, we investigated the functional importance of NS5 residue L162 by comparing wild-type ZIKV with the ZIKV-NS5L162A and ZIKV-NS5L162G mutants. RNA sequencing was performed in A549 cells that were mock infected or infected with wild-type or mutant ZIKV to characterize virus-induced transcriptional responses and determine how substitutions at NS5 residue L162 alter host gene expression. These data provide a genome-wide resource for defining NS5-dependent regulation of innate immune and antiviral responses.2026/08/20GSE344436GSM9978960GSM9978962GSM9978961GSM9978964GSM9978963GSM9978966GSM9978965GSM9978968GSM9978967GSM9978959GSM9978958GSM997896929480344436Homo sapiens