{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344506/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344506"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial Transcriptomics to Investigate the Impact of HIV/ART on DLBCL Tumorigenesis and Tumor Microenvironment","description":"The tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in diffuse large B-cell lymphoma (DLBCL), but HIV-associated DLBCL remains poorly understood. We performed spatial transcriptomics on pre-treatment DLBCL biopsies to characterize the TIME and tumor-intrinsic features across a spectrum of HIV-associated immune dysregulation. Our analysis revealed distinct immune architectures shaped by HIV status and antiretroviral therapy (ART) exposure, with implications for immunotherapeutic strategies in a population historically excluded from such trials.","dates":{"publication":"2026/09/24"},"accession":"GSE344506","cross_references":{"GSM":["GSM9980533","GSM9980511","GSM9980512","GSM9980534","GSM9980535","GSM9980513","GSM9980514","GSM9980530","GSM9980531","GSM9980532","GSM9980510","GSM9980508","GSM9980509","GSM9980526","GSM9980504","GSM9980505","GSM9980527","GSM9980506","GSM9980528","GSM9980529","GSM9980507","GSM9980522","GSM9980523","GSM9980524","GSM9980525","GSM9980520","GSM9980521","GSM9980519","GSM9980515","GSM9980516","GSM9980517","GSM9980518"],"GPL":["11154"],"GSE":["344506"],"taxon":["Homo sapiens"]}}