GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344506/primaryOK200OtherHomo sapiensOtherhttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344506GEOGSEfalseSpatial Transcriptomics to Investigate the Impact of HIV/ART on DLBCL Tumorigenesis and Tumor MicroenvironmentThe tumor immune microenvironment (TIME) and tumor heterogeneity shape prognosis and therapeutic response in diffuse large B-cell lymphoma (DLBCL), but HIV-associated DLBCL remains poorly understood. We performed spatial transcriptomics on pre-treatment DLBCL biopsies to characterize the TIME and tumor-intrinsic features across a spectrum of HIV-associated immune dysregulation. Our analysis revealed distinct immune architectures shaped by HIV status and antiretroviral therapy (ART) exposure, with implications for immunotherapeutic strategies in a population historically excluded from such trials.2026/09/24GSE344506GSM9980533GSM9980511GSM9980512GSM9980534GSM9980535GSM9980513GSM9980514GSM9980530GSM9980531GSM9980532GSM9980510GSM9980508GSM9980509GSM9980526GSM9980504GSM9980505GSM9980527GSM9980506GSM9980528GSM9980529GSM9980507GSM9980522GSM9980523GSM9980524GSM9980525GSM9980520GSM9980521GSM9980519GSM9980515GSM9980516GSM9980517GSM998051811154344506Homo sapiens