{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344585/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344585"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gene expression analysis of HSD17B4 knock-out breast cancer cells","description":"HER2-positive breast cancer has a high chance of achieving pathological complete response when HSD17B4, responsible for peroxisomal β-oxidation of very long-chain fatty acids and estradiol, is methylation-silenced. Here, we aimed to identify the underlying molecular mechanism. We conducted RNA-seq analysis and Gene Set Enrichment Analysis to make an unbiased search for genes driven by HSD17B4 KO. Analysis of the pathways upregulated by HSD17B4 depletion revealed a gene network associated with oxidative phosphorylation, using the KEGG database, and that associated with the mitochondrial respiratory chain, using the GOBP terms.","dates":{"publication":"2026/09/01"},"accession":"GSE344585","cross_references":{"GSM":["GSM9981864","GSM9981865","GSM9981862","GSM9981863"],"GPL":["29480"],"GSE":["344585"],"taxon":["Homo sapiens"]}}