GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344585/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344585GEOGSEfalseGene expression analysis of HSD17B4 knock-out breast cancer cellsHER2-positive breast cancer has a high chance of achieving pathological complete response when HSD17B4, responsible for peroxisomal β-oxidation of very long-chain fatty acids and estradiol, is methylation-silenced. Here, we aimed to identify the underlying molecular mechanism. We conducted RNA-seq analysis and Gene Set Enrichment Analysis to make an unbiased search for genes driven by HSD17B4 KO. Analysis of the pathways upregulated by HSD17B4 depletion revealed a gene network associated with oxidative phosphorylation, using the KEGG database, and that associated with the mitochondrial respiratory chain, using the GOBP terms.2026/09/01GSE344585GSM9981864GSM9981865GSM9981862GSM998186329480344585Homo sapiens