{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344859/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344859"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanoma","description":"Acquired resistance to BRAF inhibition is accompanied by broad gene-expression remodeling. We profiled parental A375 and acquired BRAF-inhibitor-resistant A375R melanoma cells using paired input and polysome-associated RNA sequencing and determined the acute response of A375R cells to the eIF4A inhibitor CR-1-31-B. An independent total-RNA-seq experiment measured later RNA-abundance responses after 24 h. These data distinguish resistance-associated RNA-abundance and translation-efficiency regulation and define early and later molecular responses to eIF4A inhibition.","dates":{"publication":"2026/09/03"},"accession":"GSE344859","cross_references":{"GSM":["GSM9986618","GSM9986619","GSM9986616","GSM9986617","GSM9986658","GSM9986614","GSM9986659","GSM9986615","GSM9986656","GSM9986612","GSM9986657","GSM9986613","GSM9986654","GSM9986610","GSM9986611","GSM9986655","GSM9986652","GSM9986653","GSM9986650","GSM9986651","GSM9986609","GSM9986607","GSM9986608","GSM9986605","GSM9986649","GSM9986606","GSM9986603","GSM9986647","GSM9986648","GSM9986604","GSM9986645","GSM9986601","GSM9986602","GSM9986646","GSM9986643","GSM9986600","GSM9986644","GSM9986641","GSM9986642","GSM9986640","GSM9986638","GSM9986639","GSM9986636","GSM9986637","GSM9986634","GSM9986635","GSM9986632","GSM9986633","GSM9986630","GSM9986631","GSM9986629","GSM9986627","GSM9986628","GSM9986625","GSM9986626","GSM9986623","GSM9986624","GSM9986621","GSM9986622","GSM9986620"],"GPL":["37309"],"GSE":["344859"],"taxon":["Homo sapiens"]}}