GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344859/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344859GEOGSEfalseeIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanomaAcquired resistance to BRAF inhibition is accompanied by broad gene-expression remodeling. We profiled parental A375 and acquired BRAF-inhibitor-resistant A375R melanoma cells using paired input and polysome-associated RNA sequencing and determined the acute response of A375R cells to the eIF4A inhibitor CR-1-31-B. An independent total-RNA-seq experiment measured later RNA-abundance responses after 24 h. These data distinguish resistance-associated RNA-abundance and translation-efficiency regulation and define early and later molecular responses to eIF4A inhibition.2026/09/03GSE344859GSM9986618GSM9986619GSM9986616GSM9986617GSM9986614GSM9986658GSM9986659GSM9986615GSM9986656GSM9986612GSM9986657GSM9986613GSM9986654GSM9986610GSM9986611GSM9986655GSM9986652GSM9986653GSM9986650GSM9986651GSM9986609GSM9986607GSM9986608GSM9986605GSM9986649GSM9986606GSM9986603GSM9986647GSM9986648GSM9986604GSM9986645GSM9986601GSM9986602GSM9986646GSM9986643GSM9986600GSM9986644GSM9986641GSM9986642GSM9986640GSM9986638GSM9986639GSM9986636GSM9986637GSM9986634GSM9986635GSM9986632GSM9986633GSM9986630GSM9986631GSM9986629GSM9986627GSM9986628GSM9986625GSM9986626GSM9986623GSM9986624GSM9986621GSM9986622GSM998662037309344859Homo sapiens