{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344928/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344928"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"CD84 Determines Differential Fates of Pro-fibrotic Macrophages [RNA-seq]","description":"To define the transcriptional effects of CD84 engagement, bone marrow-derived macrophages (BMDMs) from wild-type and Cd84-knockout mice were stimulated with mouse recombinant CD84 (rCD84) and analyzed by bulk RNA sequencing. CD84 engagement induced inflammatory, chemotactic, survival, and adhesion-related gene programs in wild-type macrophages, whereas these responses were markedly reduced by Cd84 deletion. Pathway analysis highlighted cytokine activity, inflammatory responses, leukocyte chemotaxis, focal adhesion, TNF signaling, and JAK/STAT signaling. These findings establish CD84 as a key regulator of macrophage activation and pro-fibrotic transcriptional programming.","dates":{"publication":"2026/09/25"},"accession":"GSE344928","cross_references":{"GSM":["GSM9988143","GSM9988132","GSM9988142","GSM9988141","GSM9988140","GSM9988139","GSM9988138","GSM9988137","GSM9988136","GSM9988135","GSM9988134","GSM9988133"],"GPL":["34290"],"GSE":["344928"],"taxon":["Mus musculus"]}}