GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE344nnn/GSE344928/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE344928GEOGSEfalseCD84 Determines Differential Fates of Pro-fibrotic Macrophages [RNA-seq]To define the transcriptional effects of CD84 engagement, bone marrow-derived macrophages (BMDMs) from wild-type and Cd84-knockout mice were stimulated with mouse recombinant CD84 (rCD84) and analyzed by bulk RNA sequencing. CD84 engagement induced inflammatory, chemotactic, survival, and adhesion-related gene programs in wild-type macrophages, whereas these responses were markedly reduced by Cd84 deletion. Pathway analysis highlighted cytokine activity, inflammatory responses, leukocyte chemotaxis, focal adhesion, TNF signaling, and JAK/STAT signaling. These findings establish CD84 as a key regulator of macrophage activation and pro-fibrotic transcriptional programming.2026/09/25GSE344928GSM9988143GSM9988132GSM9988142GSM9988141GSM9988140GSM9988139GSM9988138GSM9988137GSM9988136GSM9988135GSM9988134GSM998813334290344928Mus musculus