{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345213/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345213"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of LPS-stimulated RAW 264.7 macrophages with or without osteopontin treatment","description":"Osteopontin (OPN/SPP1) has been implicated in the persistence of inflammatory macrophages in osteoarthritis synovium. This study examined transcriptomic changes induced by OPN in LPS-stimulated RAW 264.7 mouse macrophages. Cells were treated with LPS alone or pretreated with recombinant mouse OPN before LPS stimulation, and RNA-seq was performed using three independent biological replicates per condition. The resulting profiles were used to evaluate OPN-associated transcriptional programs in inflammatory macrophages, including pathways related to cell proliferation and apoptosis.","dates":{"publication":"2026/09/01"},"accession":"GSE345213","cross_references":{"GSM":["GSM9999607","GSM9999608","GSM9999605","GSM9999606","GSM9999603","GSM9999604"],"GPL":["24247"],"GSE":["345213"],"taxon":["Mus musculus"]}}