GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345213/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345213GEOGSEfalseTranscriptomic profiling of LPS-stimulated RAW 264.7 macrophages with or without osteopontin treatmentOsteopontin (OPN/SPP1) has been implicated in the persistence of inflammatory macrophages in osteoarthritis synovium. This study examined transcriptomic changes induced by OPN in LPS-stimulated RAW 264.7 mouse macrophages. Cells were treated with LPS alone or pretreated with recombinant mouse OPN before LPS stimulation, and RNA-seq was performed using three independent biological replicates per condition. The resulting profiles were used to evaluate OPN-associated transcriptional programs in inflammatory macrophages, including pathways related to cell proliferation and apoptosis.2026/09/01GSE345213GSM9999607GSM9999608GSM9999605GSM9999606GSM9999603GSM999960424247345213Mus musculus