GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345297/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345297GEOGSEfalseEffect of depletion of Grina on gene expression during HSV-1 infection of BMDMsTo investigate the role of Grina in HSV-1-induced signaling pathways, we isolated total RNA from Grina-knockout (Grina-KO) BMDMs and their wild-type (WT) controls, with or without HSV-1 infection. Bone marrow-derived macrophages were generated from Grina-floxed (Grina-fl/fl) and Lyz2-Cre-mediated Grina-KO mice, and were mock-infected or infected with HSV-1 (MOI = 1) for 4 hours. Total RNA was extracted from four biological replicates per condition, representing four experimental groups: WT mock, WT HSV-1, KO mock, and KO HSV-1. This dataset enables comprehensive identification of Grina-dependent transcriptional responses during HSV-1 infection, providing insights into the crosstalk between Grina-mediated signaling and antiviral innate immunity.2026/09/01GSE345297GSM10001110GSM10001109GSM10001108GSM10001114GSM10001103GSM10001113GSM10001112GSM10001111GSM10001107GSM10001118GSM10001106GSM10001117GSM10001116GSM10001105GSM10001104GSM1000111530215345297Mus musculus