{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345344/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345344"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Liver transcriptome of ANDY mice on niacin-free diet and following dietary recovery (RNA-seq)","description":"RNA-sequencing of liver tissue from ANDY mice (transgenic mice with doxycycline-inducible expression of human ACMSD, conferring acquired dependency on dietary niacin for NAD synthesis). Male ANDY mice received doxycycline in drinking water and were maintained for 21 weeks on a niacin-replete control diet (CD) or a niacin-free diet (NFD) to induce chronic NAD deficiency, or were maintained on NFD for 15 weeks and then switched to CD for 6 weeks to assess recovery (Rec). Liver was collected at the end of the feeding trial for bulk RNA-seq to characterize transcriptional changes associated with NAD deficiency and dietary recovery (Fig. 5a, j-l; Supplementary Fig. 5g). This dataset was generated in support of: Benitez-Rosendo, A. & Feuz, M. B. et al. 'Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes.' Nature Communications (in revision; NCOMMS-26-053722-T).","dates":{"publication":"2026/09/08"},"accession":"GSE345344","cross_references":{"GSM":["GSM10001936","GSM10001935","GSM10001934","GSM10001933","GSM10001929","GSM10001939","GSM10001938","GSM10001937","GSM10001932","GSM10001943","GSM10001931","GSM10001942","GSM10001930","GSM10001941","GSM10001940"],"GPL":["30172"],"GSE":["345344"],"taxon":["Mus musculus"]}}