{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345464/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":[" Mus musculus","Homo sapiens"],"gds_type":[" Genome binding/occupancy profiling by high throughput sequencing","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345464"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Compartment-specific PPARδ activity controls the outcome of cancer – immune cell competition and immunotherapy efficacy","description":"Most patients with solid tumors fail to sustain anti-tumor immunity, in part because immune cells cannot outcompete cancer cells inside the immunosuppressive tumor microenvironment. Here, we identify the lipid-sensing transcription factor PPARδ as a compartment-specific determinant of cancer-immune fitness balance and immunotherapy efficacy. Activating PPARδ in cancer cells promotes their growth and impairs anti-tumor immunity, whereas activating it in immune cells drives tumor suppression and overrides tumor-promoting effects of cancer-intrinsic activation.Mechanistically, PPARδ enhances CD8+ T cell fitness against cancer through effector-associated chromatin and remodeling and Cpt1a-mediated fatty acid oxidation, which is partly necessary but not sufficient.Therapeutically, PPARδ-activated CD8+ T cells sensitize immunotherapy resistant microsatellite stable (MSS) metastatic colorectal cancer to checkpoint blockade in mice, and pharmacologic or genetic PPARδ activation enhances human CAR-T cell function. These findings identify compartment-specific PPARδ activity as a targetable driver of immune cell fitness that can be harnessed to improve outcomes in immunotherapy-resistant tumors.","dates":{"publication":"2026/08/31"},"accession":"GSE345464","cross_references":{"GSM":["GSM10005097","GSM10005096","GSM10005099","GSM10005098","GSM10005093","GSM10005092","GSM10005095","GSM10005094","GSM10005091","GSM10005090","GSM10005127","GSM10005126","GSM10005123","GSM10005122","GSM10005089","GSM10005125","GSM10005124","GSM10005086","GSM10005085","GSM10005088","GSM10005121","GSM10005087","GSM10005120","GSM10005082","GSM10005081","GSM10005084","GSM10005083","GSM10005080","GSM10005119","GSM10005116","GSM10005115","GSM10005118","GSM10005117","GSM10005079","GSM10005112","GSM10005111","GSM10005078","GSM10005114","GSM10005113","GSM10005075","GSM10005074","GSM10005110","GSM10005077","GSM10005076","GSM10005071","GSM10005070","GSM10005073","GSM10005072","GSM10005109","GSM10005108","GSM10005105","GSM10005104","GSM10005107","GSM10005106","GSM10005101","GSM10005100","GSM10005103","GSM10005102"],"GPL":["37309","37305"],"GSE":["345464"],"taxon":[" Mus musculus","Homo sapiens"]}}