GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345488/primary200OKGenomicsMus musculusGenome binding/occupancy profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345488GEOGSEfalseAllele-specific chromatin accessibility in early adolescence mouse liver resolved on a Collaborative Cross graph pangenomeTo investigate the functional and adaptive significance of allele-specific candidate cis-regulatory elements (cCREs), we generated ATAC-seq on liver tissue from two 25-day-old F1 hybrid mice, bred from a CC032 mother and a CC072 father. Reads were mapped to the Collaborative Cross pangenome graph and phased into CC032 and CC072 alleles. Because no peak caller currently works directly on minigraph-cactus graphs, reads were surjected to GRCm38 for peak calling with MACS2. Counting phased reads on both alleles at 102,412 reproducible cCREs and testing for differential accessibility identified 1,805 allele-specific cCREs (1.7%) between the maternal and paternal genomes. About 72% of these carry SNVs and/or SVs from one allele, and they are enriched in promoters, introns and intergenic regions as well as in SINE, LINE and LTR transposable-element subfamilies.2026/08/31GSE345488GSM10005569GSM1000556824247345488Mus musculus