{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345595/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345595"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Liver transcriptome of ANDY mice on niacin-free and control diets compared with aging in wild-type mice (RNA-seq)","description":"RNA-sequencing of liver tissue from ANDY mice (transgenic mice with doxycycline-inducible expression of human ACMSD, conferring acquired dependency on dietary niacin for NAD synthesis) and from wild-type C57BL/6J mice, used to compare transcriptional changes associated with chronic NAD deficiency to those associated with natural aging. Male ANDY mice received a niacin-replete control diet (CD) or niacin-free diet (NFD), with doxycycline induction, for 6 months (or, for one short-term arm, 10 weeks); additional arms in the same sequencing batch included a control-diet group that did not receive doxycycline (no transgene induction) and a group on a second niacin-deficient diet formulation. Young (3-month-old) and aged (28-32-month-old) wild-type mice were included for comparison with natural aging. Liver was collected for bulk RNA-seq to characterize transcriptional changes associated with NAD deficiency and aging (Fig. 6a-d). This dataset was generated in support of: Benitez-Rosendo, A. & Feuz, M. B. et al. 'Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes.' Nature Communications (in revision; NCOMMS-26-053722-T).","dates":{"publication":"2026/09/08"},"accession":"GSE345595","cross_references":{"GSM":["GSM10011438","GSM10011416","GSM10011437","GSM10011418","GSM10011417","GSM10011439","GSM10011419","GSM10011452","GSM10011430","GSM10011451","GSM10011454","GSM10011432","GSM10011431","GSM10011453","GSM10011434","GSM10011456","GSM10011433","GSM10011455","GSM10011436","GSM10011457","GSM10011435","GSM10011449","GSM10011427","GSM10011448","GSM10011426","GSM10011429","GSM10011428","GSM10011441","GSM10011440","GSM10011443","GSM10011421","GSM10011442","GSM10011420","GSM10011445","GSM10011423","GSM10011422","GSM10011444","GSM10011425","GSM10011447","GSM10011446","GSM10011424","GSM10011450"],"GPL":["30172","37305"],"GSE":["345595"],"taxon":["Mus musculus"]}}