GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345595/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345595GEOGSEfalseLiver transcriptome of ANDY mice on niacin-free and control diets compared with aging in wild-type mice (RNA-seq)RNA-sequencing of liver tissue from ANDY mice (transgenic mice with doxycycline-inducible expression of human ACMSD, conferring acquired dependency on dietary niacin for NAD synthesis) and from wild-type C57BL/6J mice, used to compare transcriptional changes associated with chronic NAD deficiency to those associated with natural aging. Male ANDY mice received a niacin-replete control diet (CD) or niacin-free diet (NFD), with doxycycline induction, for 6 months (or, for one short-term arm, 10 weeks); additional arms in the same sequencing batch included a control-diet group that did not receive doxycycline (no transgene induction) and a group on a second niacin-deficient diet formulation. Young (3-month-old) and aged (28-32-month-old) wild-type mice were included for comparison with natural aging. Liver was collected for bulk RNA-seq to characterize transcriptional changes associated with NAD deficiency and aging (Fig. 6a-d). This dataset was generated in support of: Benitez-Rosendo, A. & Feuz, M. B. et al. 'Inducible chronic NAD deficiency in mice reveals multi-systemic phenotypical, metabolic, and transcriptional changes.' Nature Communications (in revision; NCOMMS-26-053722-T).2026/09/08GSE345595GSM10011438GSM10011416GSM10011437GSM10011418GSM10011417GSM10011439GSM10011419GSM10011452GSM10011430GSM10011451GSM10011454GSM10011432GSM10011431GSM10011453GSM10011434GSM10011456GSM10011433GSM10011455GSM10011436GSM10011457GSM10011435GSM10011449GSM10011427GSM10011448GSM10011426GSM10011429GSM10011428GSM10011441GSM10011440GSM10011443GSM10011421GSM10011442GSM10011420GSM10011445GSM10011423GSM10011422GSM10011444GSM10011425GSM10011447GSM10011446GSM10011424GSM100114503017237305345595Mus musculus