{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345745/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345745"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Inducible endothelial Plvap knockout RPE-choroid tissue sinlge cell transcriptomic analysis","description":"This single-cell RNA-sequencing dataset was generated to investigate cellular and transcriptional changes following endothelial PLVAP loss in the adult mouse retina–choroid. Control and inducible endothelial-specific PLVAP knockout (PLVAPiECKO) mice were analyzed 10 days after PLVAP deletion. Single-cell transcriptomic profiling was used to characterize major retinal and choroidal cell populations and to examine PLVAP-loss-associated changes in choriocapillaris endothelial cells, retinal pigment epithelial cells, and photoreceptors. The dataset provides a cellular framework for understanding how disruption of PLVAP-dependent endothelial fenestration affects vascular–tissue exchange and metabolic homeostasis in the outer retina.","dates":{"publication":"2026/09/06"},"accession":"GSE345745","cross_references":{"GSM":["GSM10015414","GSM10015413"],"GPL":["21273"],"GSE":["345745"],"taxon":["Mus musculus"]}}