GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345745/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345745GEOGSEfalseInducible endothelial Plvap knockout RPE-choroid tissue sinlge cell transcriptomic analysisThis single-cell RNA-sequencing dataset was generated to investigate cellular and transcriptional changes following endothelial PLVAP loss in the adult mouse retina–choroid. Control and inducible endothelial-specific PLVAP knockout (PLVAPiECKO) mice were analyzed 10 days after PLVAP deletion. Single-cell transcriptomic profiling was used to characterize major retinal and choroidal cell populations and to examine PLVAP-loss-associated changes in choriocapillaris endothelial cells, retinal pigment epithelial cells, and photoreceptors. The dataset provides a cellular framework for understanding how disruption of PLVAP-dependent endothelial fenestration affects vascular–tissue exchange and metabolic homeostasis in the outer retina.2026/09/06GSE345745GSM10015414GSM1001541321273345745Mus musculus