{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345780/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345780"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Multi-Omics Analysis Links GAD1 Overexpression to Purine Metabolic Reprogramming in Lung Adenocarcinoma","description":"RNA sequencing was performed to characterize transcriptomic changes associated with GAD1 overexpression in A549 lung adenocarcinoma cells. A549 cells transduced with GAD1-expressing lentiviral particles (adGAD1) were compared with A549 cells transduced with GFP control lentiviral particles (adGFP), with three biological replicates per group. Gene-level expression profiling was used to identify transcriptional changes and pathways associated with GAD1 overexpression.","dates":{"publication":"2026/09/02"},"accession":"GSE345780","cross_references":{"GSM":["GSM10016275","GSM10016274","GSM10016273","GSM10016272","GSM10016277","GSM10016276"],"GPL":["20301"],"GSE":["345780"],"taxon":["Homo sapiens"]}}