GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345780/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345780GEOGSEfalseIntegrated Multi-Omics Analysis Links GAD1 Overexpression to Purine Metabolic Reprogramming in Lung AdenocarcinomaRNA sequencing was performed to characterize transcriptomic changes associated with GAD1 overexpression in A549 lung adenocarcinoma cells. A549 cells transduced with GAD1-expressing lentiviral particles (adGAD1) were compared with A549 cells transduced with GFP control lentiviral particles (adGFP), with three biological replicates per group. Gene-level expression profiling was used to identify transcriptional changes and pathways associated with GAD1 overexpression.2026/09/02GSE345780GSM10016275GSM10016274GSM10016273GSM10016272GSM10016277GSM1001627620301345780Homo sapiens