{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE345nnn/GSE345950/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE345950"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Gut Microbiota Mediate the Metabolism of Colonic Prostaglandins","description":"Prostaglandins (PGs) are lipid signaling molecules that regulate diverse physiological and pathological processes, and their biosynthetic pathways are targets of widely used drugs such as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). However, previous research of PG biosynthesis has focused on host metabolic pathways, the roles of gut microbiota involved are not well understood 8. Here, we identify a colonic pathway through which gut microbes directly participate in PG metabolism and regulate colonic PG levels and their biological effects. Comparison of germ-free and conventionally raised mice reveals that the gut microbiota markedly increase the levels of multiple PGs in the colon. This effect is mediated by bacterial β-glucuronidases (GUS), which hydrolyze host-derived PG glucuronides, less active or inactive conjugates, to regenerate bioactive free PGs. GUS administration and bacterial mono-colonization in germ-free mice demonstrate a critical role for microbial GUS in regulating colonic PG levels and associated biological responses. Together, these findings reveal a previously unrecognized function of the gut microbiota in PG metabolism and identify microbial GUS enzymes as potential targets for modulating colonic PG signaling in gastrointestinal diseases.","dates":{"publication":"2026/09/04"},"accession":"GSE345950","cross_references":{"GSM":["GSM10019742","GSM10019741","GSM10019744","GSM10019743","GSM10019740","GSM10019739","GSM10019738","GSM10019746","GSM10019745","GSM10019747"],"GPL":["30172"],"GSE":["345950"],"taxon":["Mus musculus"]}}