{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346071/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346071"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hippocampal transcriptomic profiling of mice after acute sub-thermal 2.65 GHz radiofrequency radiation exposure","description":"Radiofrequency radiation (RFR) is the most widespread form of artificial electromagnetic exposure, yet whether sub-thermal RFR alters hippocampal molecular programs remains poorly understood. We performed bulk RNA sequencing on hippocampal tissue from male C57BL/6N mice immediately after a single 3-h exposure to 2.65 GHz continuous-wave RFR at a whole-body average specific absorption rate (SAR) of 5.9 W/kg (maximum core-temperature rise <0.6 °C), with sham-exposed mice as controls (n=5 per group). A total of 2133 differentially expressed genes (1033 up-regulated and 1100 down-regulated; DESeq2, p value <=0.05, |log2FoldChange|>=0.0) were identified. Gene Ontology and KEGG enrichment revealed prominent perturbation of postsynaptic-organization, cognition and learning-related terms, as well as circadian entrainment, calcium-signaling and synaptic pathways. Protein-protein interaction analysis placed calcium-signaling genes (Cacna1a, Cacna1c, Cacna1i, Cacna2d1, Cacng3, Grin2a and Ryr2) at core network nodes, and independent qPCR validated down-regulation of Cacna1c (encoding the L-type CaV1.2 alpha1C subunit), Cacna2d1 and Grin2a. These data provide a molecular basis linking sub-thermal RFR to suppressed hippocampal neuronal activity and transient cognitive impairment.","dates":{"publication":"2026/09/08"},"accession":"GSE346071","cross_references":{"GSM":["GSM10022514","GSM10022515","GSM10022516","GSM10022517","GSM10022518","GSM10022509","GSM10022510","GSM10022511","GSM10022512","GSM10022513"],"GPL":["24247"],"GSE":["346071"],"taxon":["Mus musculus"]}}