{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346108/"]},"type":"primary"},"statusCodeValue":200,"statusCode":"OK"}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346108"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"CPEB1 Overexpression Rewires Alternative Splicing in T98G Cells: A Resource for Alzheimer's Disease Research","description":"Alzheimer's disease is a multifactorial neurodegenerative disorder with incompletely understood molecular mechanisms. Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an RNA-binding protein implicated in post-transcriptional regulation and synaptic function, but its regulatory network in human neural cells remains underexplored. In this study, bulk RNA sequencing was performed on T98G human glioblastoma cells transfected with a CPEB1 overexpression construct or the corresponding empty-vector control. Differential gene expression and alternative splicing analyses were performed using DESeq2 and the ABLas pipeline, respectively. Functional enrichment analysis and comparison with Alzheimer's disease-associated gene sets were used to identify candidate CPEB1-regulated genes and splicing events relevant to Alzheimer's disease research.","dates":{"publication":"2026/09/06"},"accession":"GSE346108","cross_references":{"GSM":["GSM10024692","GSM10024694","GSM10024693","GSM10024696","GSM10024695","GSM10024697"],"GPL":["24676"],"GSE":["346108"],"taxon":["Homo sapiens"]}}