GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346108/primary200OKTranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346108GEOGSEfalseCPEB1 Overexpression Rewires Alternative Splicing in T98G Cells: A Resource for Alzheimer's Disease ResearchAlzheimer's disease is a multifactorial neurodegenerative disorder with incompletely understood molecular mechanisms. Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an RNA-binding protein implicated in post-transcriptional regulation and synaptic function, but its regulatory network in human neural cells remains underexplored. In this study, bulk RNA sequencing was performed on T98G human glioblastoma cells transfected with a CPEB1 overexpression construct or the corresponding empty-vector control. Differential gene expression and alternative splicing analyses were performed using DESeq2 and the ABLas pipeline, respectively. Functional enrichment analysis and comparison with Alzheimer's disease-associated gene sets were used to identify candidate CPEB1-regulated genes and splicing events relevant to Alzheimer's disease research.2026/09/06GSE346108GSM10024692GSM10024694GSM10024693GSM10024696GSM10024695GSM1002469724676346108Homo sapiens