{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346272/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"," Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346272"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"An Intra-BET Epigenetic Mechanism Driven by BRD4 Controls Pancreatic α-cell Expansion [scRNA-seq]","description":"This study investigates the role of BET family member BRD4 in pancreatic islet organoid differentiation and endocrine cell development. Single-cell RNA sequencing was performed to characterize transcriptomic changes across three experimental systems: (1) human islet organoids following adenovirus-mediated BRD4 overexpression (B4OV) versus control; (2) pancreatic islets from α-cell-specific Brd4 knockout (αKO) mice versus control mice; and (3) stage 5 pancreatic endocrine progenitors following combined BRD4 activation and BRD2 suppression (B2sB4) versus control, after differentiation to stage 6. The dataset enables identification of BRD4-regulated gene expression programs and cellular heterogeneity during pancreatic endocrine differentiation.","dates":{"publication":"2026/09/10"},"accession":"GSE346272","cross_references":{"GSM":["GSM10031542","GSM10031541","GSM10031544","GSM10031543","GSM10031540","GSM10031539"],"GPL":["34284","34290"],"GSE":["346272"],"taxon":["Mus musculus"," Homo sapiens"]}}