{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346333/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346333"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell transcriptomic analysis of B-cell-dependent gastric cellular responses during chronic Helicobacter felis infection","description":"Chronic Helicobacter infection induces gastric inflammation and metaplastic changes through interactions among epithelial, stromal, and immune-cell populations. This study used single-cell RNA sequencing to determine how B-cell deficiency alters the gastric cellular microenvironment during chronic Helicobacter felis infection. Total gastric cell suspensions were prepared from lesser-curvature tissue containing the fundus and corpus of uninfected wild-type, H. felis-infected wild-type, and H. felis-infected JH-deficient mice. The dataset contains epithelial, stromal, and immune-cell populations and enables analysis of genotype- and infection-dependent differences in cellular composition, transcriptional programs, and intercellular communication.","dates":{"publication":"2026/09/21"},"accession":"GSE346333","cross_references":{"GSM":["GSM10032094","GSM10032095","GSM10032092","GSM10032093","GSM10032091"],"GPL":["24247"],"GSE":["346333"],"taxon":["Mus musculus"]}}