GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346333/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346333GEOGSEfalseSingle-cell transcriptomic analysis of B-cell-dependent gastric cellular responses during chronic Helicobacter felis infectionChronic Helicobacter infection induces gastric inflammation and metaplastic changes through interactions among epithelial, stromal, and immune-cell populations. This study used single-cell RNA sequencing to determine how B-cell deficiency alters the gastric cellular microenvironment during chronic Helicobacter felis infection. Total gastric cell suspensions were prepared from lesser-curvature tissue containing the fundus and corpus of uninfected wild-type, H. felis-infected wild-type, and H. felis-infected JH-deficient mice. The dataset contains epithelial, stromal, and immune-cell populations and enables analysis of genotype- and infection-dependent differences in cellular composition, transcriptional programs, and intercellular communication.2026/09/21GSE346333GSM10032094GSM10032095GSM10032092GSM10032093GSM1003209124247346333Mus musculus