{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346716/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Homo sapiens"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346716"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"NWU Study 3- SLAM-seq timecourse of KOLF2.2J hiPSC after Auxin-induced protein degradation of specific gene products","description":"This study investigates the impact of gene products on nscent transcription in growing hiPSC at 0, 6 & 24 hours after acute protein depletion. Crispr editing was used to add an auxin-dependent degron to the C-termini of gene products expressed from the endogeneous loci and to insert an auxin-responsive degradation E3 ligase to the AAVS locus. Rapid (<30 min), specific target protein degradation in KOLF2.2J hiPSCs was induced by a synthetic auxin derivative (5-Ad-IAA) and bulk ATAC-seq was performed at timepoints to define early (6 hr) and later (24 hr) downstream transcriptional dependencies.","dates":{"publication":"2026/09/12"},"accession":"GSE346716","cross_references":{"GSM":["GSM10039304","GSM10039303","GSM10039306","GSM10039305","GSM10039308","GSM10039307","GSM10039300","GSM10039302","GSM10039301","GSM10039098","GSM10039097","GSM10039099","GSM10039090","GSM10039092","GSM10039091","GSM10039094","GSM10039093","GSM10039096","GSM10039095","GSM10039087","GSM10039086","GSM10039089","GSM10039088","GSM10039081","GSM10039080","GSM10039083","GSM10039082","GSM10039085","GSM10039084","GSM10039197","GSM10039076","GSM10039075","GSM10039196","GSM10039199","GSM10039078","GSM10039198","GSM10039077","GSM10039079","GSM10039191","GSM10039070","GSM10039190","GSM10039072","GSM10039193","GSM10039192","GSM10039071","GSM10039195","GSM10039074","GSM10039194","GSM10039073","GSM10039186","GSM10039065","GSM10039185","GSM10039064","GSM10039188","GSM10039067","GSM10039066","GSM10039187","GSM10039069","GSM10039189","GSM10039068","GSM10039180","GSM10039182","GSM10039061","GSM10039060","GSM10039181","GSM10039063","GSM10039184","GSM10039183","GSM10039062","GSM10039175","GSM10039054","GSM10039296","GSM10039295","GSM10039174","GSM10039053","GSM10039298","GSM10039177","GSM10039056","GSM10039297","GSM10039176","GSM10039055","GSM10039179","GSM10039058","GSM10039178","GSM10039057","GSM10039299","GSM10039059","GSM10039290","GSM10039292","GSM10039171","GSM10039050","GSM10039291","GSM10039170","GSM10039052","GSM10039294","GSM10039173","GSM10039172","GSM10039051","GSM10039293","GSM10039039","GSM10039043","GSM10039285","GSM10039164","GSM10039163","GSM10039042","GSM10039284","GSM10039166","GSM10039045","GSM10039287","GSM10039286","GSM10039165","GSM10039044","GSM10039289","GSM10039168","GSM10039047","GSM10039046","GSM10039288","GSM10039167","GSM10039049","GSM10039169","GSM10039048","GSM10039281","GSM10039160","GSM10039280","GSM10039283","GSM10039162","GSM10039041","GSM10039040","GSM10039282","GSM10039161","GSM10039029","GSM10039149","GSM10039032","GSM10039274","GSM10039153","GSM10039152","GSM10039031","GSM10039273","GSM10039155","GSM10039034","GSM10039276","GSM10039275","GSM10039154","GSM10039033","GSM10039278","GSM10039157","GSM10039036","GSM10039277","GSM10039156","GSM10039035","GSM10039159","GSM10039038","GSM10039158","GSM10039037","GSM10039279","GSM10039270","GSM10039272","GSM10039151","GSM10039030","GSM10039271","GSM10039150","GSM10039139","GSM10039259","GSM10039138","GSM10039263","GSM10039142","GSM10039262","GSM10039141","GSM10039265","GSM10039144","GSM10039143","GSM10039264","GSM10039146","GSM10039267","GSM10039266","GSM10039145","GSM10039269","GSM10039148","GSM10039268","GSM10039147","GSM10039261","GSM10039140","GSM10039260","GSM10039249","GSM10039128","GSM10039248","GSM10039127","GSM10039129","GSM10039252","GSM10039131","GSM10039251","GSM10039130","GSM10039254","GSM10039133","GSM10039132","GSM10039253","GSM10039135","GSM10039256","GSM10039255","GSM10039134","GSM10039258","GSM10039137","GSM10039257","GSM10039136","GSM10039250","GSM10039238","GSM10039117","GSM10039237","GSM10039116","GSM10039119","GSM10039239","GSM10039118","GSM10039241","GSM10039120","GSM10039240","GSM10039243","GSM10039122","GSM10039242","GSM10039121","GSM10039245","GSM10039124","GSM10039123","GSM10039244","GSM10039126","GSM10039247","GSM10039246","GSM10039125","GSM10039106","GSM10039227","GSM10039226","GSM10039105","GSM10039229","GSM10039108","GSM10039228","GSM10039107","GSM10039109","GSM10039230","GSM10039232","GSM10039111","GSM10039231","GSM10039110","GSM10039234","GSM10039113","GSM10039112","GSM10039233","GSM10039115","GSM10039236","GSM10039235","GSM10039114","GSM10039216","GSM10039215","GSM10039218","GSM10039217","GSM10039219","GSM10039221","GSM10039100","GSM10039220","GSM10039223","GSM10039102","GSM10039222","GSM10039101","GSM10039225","GSM10039104","GSM10039103","GSM10039224","GSM10039205","GSM10039204","GSM10039207","GSM10039206","GSM10039209","GSM10039208","GSM10039210","GSM10039212","GSM10039211","GSM10039214","GSM10039213","GSM10039201","GSM10039200","GSM10039203","GSM10039202"],"GPL":["24676"],"GSE":["346716"],"taxon":["Homo sapiens"]}}