{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346722/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Other"],"species":["Macaca fascicularis"],"gds_type":["Other"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346722"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Spatial compartmentalization shapes distinct germinal center states during respiratory viral infection","description":"Germinal centers (GCs) typically form within the lymph node cortex, but whether proliferating B-cell aggregates in the medulla engage GC-associated programs remains unclear. In this study, mediastinal lymph nodes from SARS-CoV-2-infected cynomolgus macaques were analyzed using Xenium spatial transcriptomics to characterize conventional cortical GCs (cGCs) and LYVE1-associated medullary GC structures (mGCs). A 377-target Xenium Human Multi-Cancer Panel was used to profile their transcriptional, cellular, and spatial features. The dataset enables comparison of GC organization across distinct anatomical compartments within lung-draining lymph nodes.","dates":{"publication":"2026/09/13"},"accession":"GSE346722","cross_references":{"GSM":["GSM10039418","GSM10039417"],"GPL":["37502"],"GSE":["346722"],"taxon":["Macaca fascicularis"]}}