{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346846/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346846"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Anti-PD1 during T cell priming enhances long-term protection against metastatic tumors by epigenetically tuning T cell exhaustion","description":"In cancer, CD8+ T cell responses are dominated by exhausted T cells, which can be reinvigorated using immune checkpoint blockade therapy and can control large tumors. However, it remains unclear which T cell fate best supports long-term immunity following initial tumor clearance or surgical resection when antigen is largely absent. To determine which T cell fate provides durable protection following surgical tumor removal and metastatic rechallenge, we modulated T cell priming using anti-PD-1, IFN-b or agonistic anti-CD40 and assessed effects on CD8+ T cell differentiation and overall survival. Strikingly, only treatment with anti-PD-1 but not IFN-b or anti-CD40 promoted improved long-term protection over surgical removal alone. Transcriptional and epigenetic profiling revealed that a circulatory, memory-like state sharing features of exhaustion characterizes the anti-tumor response during metastatic challenge in mice treated with anti-PD-1 and is associated with durable anti-tumor immunity.","dates":{"publication":"2026/09/10"},"accession":"GSE346846","cross_references":{"GSM":["GSM10041509","GSM10041508","GSM10041491","GSM10041490","GSM10041503","GSM10041502","GSM10041501","GSM10041500","GSM10041507","GSM10041506","GSM10041505","GSM10041504","GSM10041495","GSM10041494","GSM10041493","GSM10041492","GSM10041510","GSM10041499","GSM10041498","GSM10041497","GSM10041496","GSM10041514","GSM10041513","GSM10041512","GSM10041511","GSM10041517","GSM10041516","GSM10041515"],"GPL":["24247"],"GSE":["346846"],"taxon":["Mus musculus"]}}