{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346909/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Sus scrofa"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346909"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of brain regions and primary fibroblasts from BRD1 haploinsufficient Göttingen minipigs","description":"BRD1 is a chromatin-associated transcriptional regulator implicated in psychiatric disorders. To investigate the transcriptional consequences of BRD1 haploinsufficiency in a translational large-animal model, we performed RNA sequencing of multiple brain regions and primary fibroblasts from BRD1 haploinsufficient (BRD1+/-) and wild-type Göttingen minipigs. The study identifies tissue- and brain region-specific transcriptional alterations associated with reduced BRD1 function and forms part of a broader multimodal characterization of the neurodevelopmental and systemic consequences of BRD1 haploinsufficiency.","dates":{"publication":"2026/09/15"},"accession":"GSE346909","cross_references":{"GSM":["GSM10042398","GSM10042410","GSM10042399","GSM10042411","GSM10042412","GSM10042394","GSM10042395","GSM10042396","GSM10042397","GSM10042417","GSM10042418","GSM10042419","GSM10042413","GSM10042414","GSM10042415","GSM10042416","GSM10042393","GSM10042420","GSM10042421","GSM10042422","GSM10042400","GSM10042401","GSM10042423","GSM10042406","GSM10042407","GSM10042408","GSM10042409","GSM10042402","GSM10042424","GSM10042403","GSM10042425","GSM10042404","GSM10042426","GSM10042405"],"GPL":["29847"],"GSE":["346909"],"taxon":["Sus scrofa"]}}