{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE346nnn/GSE346990/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Lacticaseibacillus paracasei"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE346990"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic Supramolecular Hydrogel Reprogram Probiotic Metabolism and Enhance Therapeutic Efficacy in Periodontitis","description":"Hydrogel network dynamics can influence the biological function of encapsulated probiotics. We performed RNA sequencing to compare the transcriptional profiles of Lacticaseibacillus paracasei encapsulated in dynamic supramolecular (Lp@PP) and static covalently crosslinked (Lp@BM) hydrogels. Our analysis revealed distinct growth-associated and stress-adaptive transcriptional programs in Lp@PP and Lp@BM, respectively.","dates":{"publication":"2026/09/20"},"accession":"GSE346990","cross_references":{"GSM":["GSM10043730","GSM10043731","GSM10043732","GSM10043729","GSM10043733","GSM10043734"],"GPL":["34642"],"GSE":["346990"],"taxon":["Lacticaseibacillus paracasei"]}}