GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347031/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347031GEOGSEfalseTherapeutic HPV16 E7 Vaccination with CD137 Agonism Induces Tumour Regression and Durable Immunity in MiceTherapeutic HPV16 E7 vaccination was evaluated in the syngeneic TC-1 tumour model in female C57BL/6 mice. Bulk RNA sequencing was performed on pooled, non-adherent mononuclear cell-enriched fractions prepared from subcutaneous tumour samples. The dataset compares PBS or vehicle controls, MPLA-adjuvanted wild-type E7 vaccination, MPLA-adjuvanted recombinant overlapping peptide E7 (ROP-E7) vaccination, anti-CD137 (4-1BB) agonism, and ROP-E7 plus anti-CD137 combination therapy. The study was designed to characterise treatment-associated changes in tumour immune and stromal transcriptional signatures.2026/09/25GSE347031GSM10044577GSM10044576GSM10044578GSM10044573GSM10044572GSM10044575GSM10044574GSM10044571GSM10044570GSM1004456924247347031Mus musculus