GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347202/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347202GEOGSEfalseInvestigating PRELP–TLR2 interactions in the transcriptional control of melanoma immunogenicityProline/arginine-rich end leucine-rich repeat protein (PRELP) is an extracellular matrix-associated protein involved in tissue remodeling and immune regulation. This study investigates PRELP-associated transcriptional changes in human melanoma using bulk RNA sequencing of PRELP-low, PRELP-high, and PRELP + Toll-like receptor 2 (TLR2) co-transfected BUF1088 cells. PRELP-high cells were generated by experimental PRELP overexpression, while the PRELP + TLR2 group was generated by co-transfection with PRELP and TLR2 expression constructs. Inclusion of the co-transfected samples enables investigation of how TLR2 expression influences PRELP-associated transcriptional programs. Comparative analysis of PRELP-high versus PRELP-low cells revealed broad transcriptomic remodeling, including increased expression of interferon-responsive genes and enrichment of JAK–STAT signaling, chemokine signaling, and MHC class I antigen processing and presentation pathways. These data support a role for PRELP in promoting tumor-intrinsic immune-reactive transcriptional programs and provide a resource for investigating the relationship between extracellular matrix components, TLR2 signaling, and melanoma immune regulation. This work was supported by German Research Foundation (DFG) (KS): 558635546 and EFRE Immu-pATienT (BS, CW): ZS/2024/01/183830.2026/09/28GSE347202GSM10047339GSM10047337GSM10047338GSM10047336GSM10047344GSM10047342GSM10047343GSM10047340GSM1004734124676347202Homo sapiens[42813001]