{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347361/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347361"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Sdhd hypermethylation promotes succinate accumulation and NLRP3 pyroptosis in septic lung injury","description":"To model macrophage pyroptosis, mouse primary bone marrow‑derived macrophages (BMDMs) were primed with lipopolysaccharide (LPS) followed by adenosine triphosphate (ATP) stimulation, a well‑established protocol for NLRP3 inflammasome activation. To elucidate the metabolic and transcriptomic changes associated with pyroptosis, we performed RNA sequencing (RNA‑seq) on BMDMs treated with LPS alone or LPS + ATP.","dates":{"publication":"2026/09/20"},"accession":"GSE347361","cross_references":{"GSM":["GSM10051507","GSM10051502","GSM10051504","GSM10051503","GSM10051506","GSM10051505"],"GPL":["24247"],"GSE":["347361"],"taxon":["Mus musculus"]}}