{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347403/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347403"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Hippocampal interferon-response, unfolded-protein-response and synaptic transcriptional signatures in RORgt-transgenic mice","description":"RORgt-transgenic mice provide a model of sustained Th17 bias. We performed bulk RNA sequencing of bilateral hippocampi from untreated 10-week-old male RORgt-transgenic mice and wild-type littermates (n = 3 per genotype) to characterize gene-level and gene-set transcriptional differences. RNA-seq identified a small set of FDR-significant genes and gene-set enrichment patterns involving interferon responses, unfolded protein response, and synaptic/calcineurin-related processes. The dataset is intended to support transparent reanalysis of the hippocampal transcriptomic phenotype associated with the RORgt-transgenic genotype.","dates":{"publication":"2026/09/16"},"accession":"GSE347403","cross_references":{"GSM":["GSM10052263","GSM10052264","GSM10052262","GSM10052267","GSM10052265","GSM10052266"],"GPL":["37305"],"GSE":["347403"],"taxon":["Mus musculus"]}}