GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347403/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347403GEOGSEfalseHippocampal interferon-response, unfolded-protein-response and synaptic transcriptional signatures in RORgt-transgenic miceRORgt-transgenic mice provide a model of sustained Th17 bias. We performed bulk RNA sequencing of bilateral hippocampi from untreated 10-week-old male RORgt-transgenic mice and wild-type littermates (n = 3 per genotype) to characterize gene-level and gene-set transcriptional differences. RNA-seq identified a small set of FDR-significant genes and gene-set enrichment patterns involving interferon responses, unfolded protein response, and synaptic/calcineurin-related processes. The dataset is intended to support transparent reanalysis of the hippocampal transcriptomic phenotype associated with the RORgt-transgenic genotype.2026/09/16GSE347403GSM10052263GSM10052264GSM10052262GSM10052267GSM10052265GSM1005226637305347403Mus musculus