{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347564/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347564"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Bulk RNA-seq of human iPSC-derived epithelial cysts and trunk morphs","description":"This series contains bulk RNA-sequencing data from human induced pluripotent stem cell-derived epithelial cysts and trunk morphs generated on microwell chips with localized delivery of BMP4 from coated beads. Four sets of libraries are included: (1) pluripotent cysts collected 0, 7 and 24 h after exposure to BMP4-coated beads, used to follow induction of endogenous BMP4 expression; (2) cysts after two days of differentiation in the presence of the Activin/Nodal inhibitor A83-01, and cysts differentiated without the inhibitor, used to test whether definitive endoderm is induced under the differentiation conditions used in this study; (3) sorted neuromesodermal progenitor and lateral plate mesoderm populations; and (4) cells carrying a CRISPR interference construct targeting the BMP receptor BMPR1A compared with cells carrying a scrambled guide control. Together these data characterise the transcriptional response to localized BMP signalling and the specification of lateral plate mesoderm in this model.","dates":{"publication":"2026/09/16"},"accession":"GSE347564","cross_references":{"GSM":["GSM10055553","GSM10055552","GSM10055551","GSM10055550","GSM10055557","GSM10055556","GSM10055555","GSM10055554","GSM10055559","GSM10055558","GSM10055560","GSM10055542","GSM10055564","GSM10055563","GSM10055541","GSM10055540","GSM10055562","GSM10055561","GSM10055546","GSM10055545","GSM10055544","GSM10055543","GSM10055565","GSM10055549","GSM10055548","GSM10055547"],"GPL":["34284"],"GSE":["347564"],"taxon":["Homo sapiens"]}}