GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347564/primaryOK200TranscriptomicsHomo sapiensExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347564GEOGSEfalseBulk RNA-seq of human iPSC-derived epithelial cysts and trunk morphsThis series contains bulk RNA-sequencing data from human induced pluripotent stem cell-derived epithelial cysts and trunk morphs generated on microwell chips with localized delivery of BMP4 from coated beads. Four sets of libraries are included: (1) pluripotent cysts collected 0, 7 and 24 h after exposure to BMP4-coated beads, used to follow induction of endogenous BMP4 expression; (2) cysts after two days of differentiation in the presence of the Activin/Nodal inhibitor A83-01, and cysts differentiated without the inhibitor, used to test whether definitive endoderm is induced under the differentiation conditions used in this study; (3) sorted neuromesodermal progenitor and lateral plate mesoderm populations; and (4) cells carrying a CRISPR interference construct targeting the BMP receptor BMPR1A compared with cells carrying a scrambled guide control. Together these data characterise the transcriptional response to localized BMP signalling and the specification of lateral plate mesoderm in this model.2026/09/16GSE347564GSM10055553GSM10055552GSM10055551GSM10055550GSM10055557GSM10055556GSM10055555GSM10055554GSM10055559GSM10055558GSM10055560GSM10055542GSM10055564GSM10055563GSM10055541GSM10055540GSM10055562GSM10055561GSM10055546GSM10055545GSM10055544GSM10055543GSM10055565GSM10055549GSM10055548GSM1005554734284347564Homo sapiens