{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347712/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Mus musculus"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347712"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic profiling of CT26 tumor-bearing mice treated with novel HDAC inhibitor GNTbm-38","description":"Histone deacetylase inhibitors (HDACis) represent a promising therapeutic strategy in cancer treatment. In this study, we evaluated the therapeutic efficacy and molecular mechanisms of GNTbm-38, a novel HDAC inhibitor, using a syngeneic CT26 colon carcinoma tumor-bearing mouse model. BALB/c mice bearing subcutaneous CT26 tumors were treated with vehicle control or GNTbm-38. Bulk RNA-sequencing was performed on tumor tissues to characterize transcriptomic alterations induced by GNTbm-38. This dataset provides comprehensive gene expression profiles to elucidate the antitumor and immunomodulatory pathways regulated by GNTbm-38 in colorectal cancer.","dates":{"publication":"2026/09/17"},"accession":"GSE347712","cross_references":{"GSM":["GSM10059207","GSM10059206","GSM10059209","GSM10059208","GSM10059203","GSM10059202","GSM10059205","GSM10059204","GSM10059199","GSM10059210","GSM10059201","GSM10059211","GSM10059200"],"GPL":["24247"],"GSE":["347712"],"taxon":["Mus musculus"]}}