GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347712/primaryOK200TranscriptomicsMus musculusExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347712GEOGSEfalseTranscriptomic profiling of CT26 tumor-bearing mice treated with novel HDAC inhibitor GNTbm-38Histone deacetylase inhibitors (HDACis) represent a promising therapeutic strategy in cancer treatment. In this study, we evaluated the therapeutic efficacy and molecular mechanisms of GNTbm-38, a novel HDAC inhibitor, using a syngeneic CT26 colon carcinoma tumor-bearing mouse model. BALB/c mice bearing subcutaneous CT26 tumors were treated with vehicle control or GNTbm-38. Bulk RNA-sequencing was performed on tumor tissues to characterize transcriptomic alterations induced by GNTbm-38. This dataset provides comprehensive gene expression profiles to elucidate the antitumor and immunomodulatory pathways regulated by GNTbm-38 in colorectal cancer.2026/09/17GSE347712GSM10059207GSM10059206GSM10059209GSM10059208GSM10059203GSM10059202GSM10059205GSM10059204GSM10059199GSM10059210GSM10059201GSM10059211GSM1005920024247347712Mus musculus