{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347961/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Caenorhabditis elegans"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347961"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Dauer morphogenesis requires inhibition of DBL-1-BMP signaling by ztf-30","description":"In response to changing environments, the nematode C. elegans enters a stress-resistant diapause stage to survive adverse conditions. While the pathways controlling developmental arrest, such as insulin/ daf-2 and TGF-β/daf-7 are well characterized, mechanisms governing subsequent dauer morphogenesis remain poorly understood. Here, we report that the zinc-finger transcription factor ZTF-30 is dispensable for developmental arrest but essential for dauer morphogenesis. ztf-30 mutants form partial dauers that lack a protective thickened cuticle and specialized structures such as alae. Transcriptomics revealed that ztf-30 mutants precociously activate adult collagen expression and upregulate the DBL-1/BMP signaling pathway, which primarily modulates body size and innate immunity. These data suggest ZTF-30 represses BMP signaling. Consistent with this model, ztf-30 partial dauers show increased dbl-1 expression, increased DBL-1 signaling phenocopies ztf-30 loss, and reducing DBL-1 signaling rescues the partial dauer phenotype. During larval growth, ztf-30 loss causes ectopic hypodermal dbl-1 expression and increased body length. Ultimately, our findings establish that the active inhibition of DBL-1/BMP signaling is strictly required for proper dauer morphogenesis and we identify ZTF-30 as an essential transcriptional repressor driving this developmental shutdown.","dates":{"publication":"2026/09/19"},"accession":"GSE347961","cross_references":{"GSM":["GSM10064494","GSM10064493","GSM10064495","GSM10064492"],"GPL":["18245"],"GSE":["347961"],"taxon":["Caenorhabditis elegans"]}}