{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348038/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":[" Other","Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348038"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell RNA-seq profiling of ARID1A-loss-associated transcriptional heterogeneity and clonal diversification in pancreatic cancer cells","description":"This Series contains additional single-cell RNA-seq datasets associated with a study of how loss of epigenetic regulators, particularly ARID1A, reshapes transcriptional heterogeneity in pancreatic ductal adenocarcinoma cells. The shPseuMO-Tag system couples genetic perturbation with clonal lineage tracing. The datasets include an initial epigenetic-modifier screen, an ARID1A knockdown time course, a large-scale pooled five-shRNA experiment, acute SMARCA4 degradation, independent experiments in multiple PDAC cell lines, and matched pre-injection and lung-colonization samples. In the independent multi-cell-line experiment, BxPC3, HPAC, SW1990, and SUIT-2 were profiled using independently derived clones, whereas HPAFII was analyzed as a pooled population because stable single-cell-derived HPAFII clones could not be established.","dates":{"publication":"2026/09/22"},"accession":"GSE348038","cross_references":{"GSM":["GSM10065570","GSM10065572","GSM10065571","GSM10065574","GSM10065573","GSM10065576","GSM10065575","GSM10065578","GSM10065567","GSM10065566","GSM10065577","GSM10065569","GSM10065568","GSM10065579"],"GPL":["21697"],"GSE":["348038"],"taxon":["Homo sapiens"]}}