GEOapplication/xmlftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348038/primaryOK200TranscriptomicsHomo sapiens OtherExpression profiling by high throughput sequencinghttps://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348038GEOGSEfalseSingle-cell RNA-seq profiling of ARID1A-loss-associated transcriptional heterogeneity and clonal diversification in pancreatic cancer cellsThis Series contains additional single-cell RNA-seq datasets associated with a study of how loss of epigenetic regulators, particularly ARID1A, reshapes transcriptional heterogeneity in pancreatic ductal adenocarcinoma cells. The shPseuMO-Tag system couples genetic perturbation with clonal lineage tracing. The datasets include an initial epigenetic-modifier screen, an ARID1A knockdown time course, a large-scale pooled five-shRNA experiment, acute SMARCA4 degradation, independent experiments in multiple PDAC cell lines, and matched pre-injection and lung-colonization samples. In the independent multi-cell-line experiment, BxPC3, HPAC, SW1990, and SUIT-2 were profiled using independently derived clones, whereas HPAFII was analyzed as a pooled population because stable single-cell-derived HPAFII clones could not be established.2026/09/22GSE348038GSM10065570GSM10065572GSM10065571GSM10065574GSM10065573GSM10065576GSM10065575GSM10065578GSM10065567GSM10065566GSM10065577GSM10065569GSM10065568GSM1006557921697348038Homo sapiens