{"database":"GEO","file_versions":[{"headers":{"Content-Type":["application/json"]},"body":{"files":{"Other":["ftp://ftp.ncbi.nlm.nih.gov/geo/series/GSE348nnn/GSE348189/"]},"type":"primary"},"statusCode":"OK","statusCodeValue":200}],"scores":null,"additional":{"omics_type":["Transcriptomics"],"species":["Homo sapiens"],"gds_type":["Expression profiling by high throughput sequencing"],"full_dataset_link":["https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE348189"],"repository":["GEO"],"entry_type":["GSE"],"additional_accession":[]},"is_claimable":false,"name":"RNA-seq analysis of TGF-beta1-stimulated human RPTEC/TERT1 cells treated with mesenchymal stem cell-conditioned media","description":"Renal proximal tubular epithelial cell responses to mesenchymal stem cell-conditioned medium were examined in a TGF-beta1-induced profibrotic model. Human RPTEC/TERT1 cells were assigned to four conditions: untreated cells without TGF-beta1 or conditioned medium (NC); cells exposed to 10 ng/mL recombinant human TGF-beta1 for 24 h, followed by complete medium replacement with conditioned medium from immortalized human adipose-derived mesenchymal stem cells transfected with a negative-control miRNA mimic (TN) or a miR-29a-3p mimic (T29). TGF-beta1 was maintained at 10 ng/mL throughout the subsequent 48 h conditioned-medium treatment. Bulk mRNA sequencing was used to characterize condition-associated transcriptomic changes.","dates":{"publication":"2026/09/23"},"accession":"GSE348189","cross_references":{"GSM":["GSM10067663","GSM10067664","GSM10067662","GSM10067667","GSM10067668","GSM10067665","GSM10067666","GSM10067669","GSM10067670"],"GPL":["30173"],"GSE":["348189"],"taxon":["Homo sapiens"]}}